Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12
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چکیده
منابع مشابه
Protective Effects of Linoleic Acid against the Cytotoxicity of Palmitic Fatty Acid in Rat Cardiomyocytes
Background & Aims: Lipotoxicity is the process through which accumulation of lipid intermadiates leads to cellular dysfunction. The worldwide prevalence of cardiovascular diseases has been increased dramatically due to lipotoxicity. According to the peformed studies, saturated and unsaturated fatty acids differ significantly in their contributions to lipotoxicity. It has been r...
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Background and objectives: Nigella sativa seeds have shown to possess anti-inflammatory, anti-oxidant, trenquillizer, chemopreventive and anti-neoplastic effects. Besides, they areused as nutritional flavoring agents. We have investigated the protective effects of N. sativa seeds hexane extract and active principles against methyl phenyl pyridine (MP...
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Mycobacterium avium accumulates (14)C-palmitic acid with saturation kinetics; the process is both temperature dependent and pH sensitive. The fatty acid is incorporated into triglyceride in vivo and the conversion is detectable within 5 min after exposure of the cells to (14)C-palmitic acid. The triglyceride is rapidly utilized because (14)CO(2) evolution from it begins within 30 min after (14)...
متن کاملElevated palmitic acid production in soybeans
Soybeans (i.e., Glycine max L. Merr.) possessing a novel genetic determinant for the enhanced production of palmitic acid in the endogenously formed vegetable oil of the seeds are provided. Such genetic determinant is the homogeneous recessive fap5fap5 gene pair that has been found to be capable of formation through mutagenesis. Once formed, such genetic determinant can be readily transferred t...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2014
ISSN: 1423-0127
DOI: 10.1186/1423-0127-21-13